Animal Health Professionals

Animal Health Professionals

Questions:
(800) 944-7563

Products

ENDOVAC-Beef®

ENDOVAC-Beef

Bacterin

Totally Naked Mutant Core that doesn’t have the ability to grow Lipopolysaccharides (LPS). The core has a completely exposed cell wall that is common to all gram-negative bacteria. On label for Salmonella, E. coli, Pasteurella, Mannheimia.

Toxoid

Separate component, that is completely different than the bacterin. It is not just a loose toxin that has separated from the bacterin. It has been totally detoxified yet retains its mitogen properties through stimulation of certain Toll-Like Receptors (TLR). This makes it more than just an adjuvant and a true immunostimulant.

Application

DVMs use ENDOVAC-Beef® for several gram-negative diseases. Cell walls of all gram-negatives are exactly the same, it is only LPS that differentiates them as separate species and serotypes. Creating a gram-negative mutant that does not have the ability to grow LPS, means that we can actually make antibodies for the epitopes on the cell wall. Normal gram-negative vaccines cannot do this. The antigenicity of the LPS is too strong and the antigen presenting cells completely ignore the cell wall. By putting the gram-negative mutant in completely devoid of LPS and coupling it with a true Immunostimulant, we are able to make antibodies for epitopes all over the exposed cell wall.

Two Technologies in One Bottle

Endovac Vaccine

Unprecedented efficacy

Zero Active Endotoxins makes it safe for all ages and classes of cattle

Multiple Pathogens Covered

Immune Plus

Only immunostimulant included in a vaccine

Activates immune system for stronger responses to all vaccines

Increases antibodies, lymphocytes, and neutrophils

Endovac Vaccine

Unprecedented efficacy

Zero Active Endotoxins makes it safe for all ages and classes of cattle

Numerous Pathogens Covered

New Beef Bottle

Immune Plus

Only immunostimulant included in a vaccine

Activates immune system for stronger responses to all vaccines

Increases antibodies, lymphocytes, and neutrophils

Immune Plus

Immune Plus is an Immunostimulant made from proprietary ENDOVAC Animal Health Technology. Immune Plus raises the overall response of the immune system in the animal. This is important both for response to vaccination as well overall health at critical times. As the graphs demonstrate, two key components of the immune system, lymphocytes and antibodies, are both significantly increased with Immune Plus. Elevating the animal’s own immune response to ward off harmful pathogens, as well as enhancing the response to all administered vaccinations, are key roles of Immune Plus.

Broad Spectrum of Protection

The way most vaccines are built, multiple antigens have to be added to the vaccine to get protection from multiple diseases. This cocktail method means that the animal has to respond to lots of different antigens individually. ENDOVAC-Beef vaccine is different for two reasons. First, the way our core technology is built, it is broad spectrum with only one antigen – see diagram. Our unique antigen is the core of all gram- negative bacteria. This allows it to protect against numerous gram-negative bacterial diseases. Second, ENDOVAC-Beef is the only gram-negative vaccine to not have harmful active endotoxins. Endotoxins, also known as LPS, are not grown at all by our core antigen. This includes the toxin Lipid A, that plagues other gram-negative vaccines.

Antibody Titer LOG2 Chart
Lymphocytes Chart
2021_Gram-Negative ENDOTOXEMIA_Gram-Negative ENDOTOXEMIA
2021_Gram-Negative Bacterial Envelope