The first year using Endovac, the overall antibiotic bill was reduced by 35-40% and has held at a similar number each year since.

Steve Williams, Midland Bull Test

Randal Spare DVM

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Protect Your Cattle Against Gram Negative Septicemic Diseases caused by E.coli, Salmonella & Pasteurella With ENDOVAC-Beef®

Important Information


Provides passively transferred immunity when given in late gestation, 4 – 6 weeks prior to birth.

Safe in all trimesters of pregnancy.

Safe in lactating cattle.

36-month shelf life.

21 Day withdraw


2 ml intramuscularly

2 ml booster in 2 – 3 weeks

1 annual booster

Sizes Available

40 ml bottle/20 dose

100 ml bottle/50 dose

200 ml bottle/100 dose


Cross protection helps producers do more with less.

Cattle feedlots are an ideal environment for beef production—but also for spreading diseases that can hurt the bottom line. Gram-negative septicemias and endotoxemias can spread quickly among cattle in a confined location, increasing morbidity while reducing weight gain. Vaccination, the obvious solution to maintaining herd health, presents its own challenges. With so many potential pathogens to guard against, with each requiring a specific antibody, a cost-effective vaccination program has been extremely difficult, if not impossible. ENDOVAC-Beef® with IMMUNE Plus® provides a solution.

The benefits of ENDOVAC-Beef® with Immune Plus®

New immunological approach: protects against gram-negative endotoxemic diseases.

Cross-protection provided against endotoxemia caused by E. coli, Salmonella and Pasteurella in cattle; Salmonella and E. coli in horses; and Salmonella choleraesuis and Salmonella typhimurium in swine.

ENDOVAC-Beef is the first vaccine with USDA label for “protection against the clinical signs of E. coli mastitis”.

ENDOVAC-Beef® with Immune Plus® offers the Producer options

ENDOVAC-Beef® with Immune Plus® offers the Producer an option which can reduce the economic losses associated with Gram negative septicemias and endotoxemias in cattle. Recent feedlot studies resulted in a $3.25 per head savings in medical costs and significant reduction in pulls/re-pulls for vaccinated cattle vs. non-vaccinated cattle. Recently, significant reductions in incidence, sick days and mortality due to E. coli in beef cows has been demonstrated.

How does ENDOVAC-Beef® work?

The development of a mutant bacterin combined with an immune stimulant has resulted in an effective cross-protective vaccine. This vaccine offers protection against several Gram negative endotoxins, common causes of economic loss to beef producers.

How is ENDOVAC-Beef® administered?

Inject 2ml into the musculature of healthy cattle. Repeat in 2 or 3 weeks.

Administer a 2ml booster dose annually. Not recommended for administration to mastitic cows or to septicemic cattle.

Consult your Veterinarian.

How is ENDOVAC-Beef® supplied?

ENDOVAC-Beef® with IMMUNE Plus® begins with a call to your veterinarian or from any major distributor.

Scientific and Economic Studies

Locate your ENDOVAC-Beef ® rep.